The protein TDP-43 (is present in all cells of our body and important for their biochemical processes. However, this protein can aggregate into large clumps in the brain, which can cause degenerative diseases such as Alzheimer's and other dementias. How exactly this happens and how these protein clumps are linked to disease is a subject of intense research. Professor Dorothee Dormann of Johannes Gutenberg University Mainz (JGU) suspects that these proteins may also assemble in healthy cells – and that this assembly on a much smaller scale is important for the normal function of the TDP-43 protein. Her research group investigates the reason for these assemblies in the TDP Assembly project, for which the European Research Council has now awarded her an ERC Consolidator Grant worth EUR 2 million (~US $2.157 million). This is one of the EU's most prestigious and valuable grants, awarded to outstanding individual scientists working on ground-breaking research. Dorothee Dormann is Professor of Molecular Cell Biology at JGU and Adjunct Director at the Institute of Molecular Biology (IMB) in Mainz.
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