DNA Origami Leads to Unexpected Discovery of Important Cell Function

Origami crane
Researchers at Karolinska Institutet (KI) have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown way. The result opens new avenues for understanding how the Notch signaling pathway works and how it is involved in several serious diseases. The study was published January 18, 2024 in Nature Communications. The open-access article is titled “Soluble and Multivalent Jag1 DNA Origami Nanopatterns Activate Notch Without Pulling Force."
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