Developing Cancer Therapies at the Intersection of Chemistry and Biology

Pioneering chemist, Nobelist, and Fellow of the AACR Academy Carolyn R. Bertozzi, PhD, leads efforts to develop cancer therapeutics against “a different type of drug target.”
Nobel Laureate Carolyn Bertozzi, PhD

A well-manicured garden turning into an overgrown jungle. That’s how Nobel Laureate Carolyn R. Bertozzi, PhD, FAACR, describes some of the changes that occur when a normal cell becomes malignant. In this case, she’s referring to changes in certain sugar molecules called sialoglycans, which are found on normal cells but grow in number and become reorganized in cancer. Dr. Bertozzi, a renowned biochemist at Stanford University, has been interested in these and other similar structures for many years. She developed a chemistry technique to study them in 2007, a groundbreaking development that led to her receiving the 2022 Nobel Prize in Chemistry. In 2023, Dr. Bertozzi was elected a Fellow of the AACR Academy and received the AACR Award for Outstanding Achievement in Chemistry in Cancer Research for this trailblazing research.

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