Decoding Cell Fate: Key Mechanism in Stem Cell Switch Identified

Daam1 protein
Stem cells can differentiate to replace dead and damaged cells. But how do stem cells decide which type of cell to become in a given situation? Using intestinal organoids, the group of Bon-Kyoung Koo, PhD, at IMBA (International Molecular Biotechnology) and the Institute for Basic Science identified a gene, Daam1, that plays an essential role, switching on the development of secretory cells in the intestine. This finding, published on November 24, 2023 in Science Advances, opens new perspectives in cancer research. The open-access article is titledIntestinal Paneth Cell Differentiation Relies on Asymmetric Regulation of Wnt Signaling by Daam1/2.”
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