Dartmouth-Led Study Provides New Insights into Phage Therapy Design

EM image showing bacteriophage docking
Results from a new Dartmouth-led study, involving collaborators at the University of Pittsburgh and Yale University and published in the journal PLoS Biology, are providing new insights into the therapeutic potential of bacteriophage (phage) therapy for treating diseases like cystic fibrosis (CF). A major challenge of treating people with CF—an inherited disease that causes sticky, thick mucus to build up in the lungs—are the persistent infections the disease causes which can lead to respiratory failure and death. The open-access PLoS Biology article was published April 23, 2024, and is titled “Lytic Bacteriophages Induce the Secretion of Antiviral and Proinflammatory Cytokines from Human Respiratory Epithelial Cells.”
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