“Cytokine Storms” & T-Cell Counts May Offer Clues on How to Treat COVID-19; Study Carried Out on Patients Hospitalized in Wuhan, China

So-called “cytokine storms” may affect the severity of COVID-19 cases by lowering T-cell counts, according to a new study published online on May 1, 2020 in Frontiers in Immunology. The open-access article is titled “Reduction and Functional Exhaustion of T Cells in Patients with Coronavirus Disease 2019 (COVID-19).” Researchers studying coronavirus cases in China found that sick patients had a significantly low number of T cells, a type of white blood cell that plays a crucial role in immune response, and that T-cell counts were negatively correlated with case severity. Interestingly, these scientists also found a high concentration of cytokines, a class of proteins that normally helps fight off infection. Too many cytokines can trigger an excessive inflammatory response known as a “cytokine storm,” which causes attacks on healthy cells. The study suggests that coronavirus does not attack T cells directly, but rather triggers the cytokine release, which then drives the depletion and exhaustion of T cells. The findings offer clues on how to target treatment for COVID-19, which has become a worldwide pandemic and a widespread threat to human health in the past few months. "We should pay more attention to T-cell counts and their function, rather than respiratory function of patients," says author Dr. Yongwen Chen of Third Military Medical University in China, adding that "more urgent, early intervention may be required in patients with low T-lymphocyte counts.” Dr. Chen says he and his co-authors became interested in examining T cells when they noticed that many of the patients they treated for COVID-19 had abnormally low numbers of lymphocytes, a type of white blood cell that includes T cells.
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