Comparison of Transcriptomic & Cytokine Responses in Colorectal Cancer (CRC); Findings Contribute to Authors’ Understanding of Molecular Bases of Efficacy and Toxicity of Chemotherapeutic Agents Often Used for Treatment of GI Cancers Such As CRC

On September 28, 2021, Oncotarget online-published the open-access article "Pan-Drug and Drug-Specific Mechanisms of 5-FU, Irinotecan (CPT-11), Oxaliplatin, and Cisplatin Identified by Comparison of Transcriptomic and Cytokine Responses of Colorectal Cancer Cells,” which reported that there was an increase in IL-8 by oxaliplatin and increase in ferritin by cisplatin which may contribute to cancer cell survival. Together, the findings here contribute to the authors' understanding of the molecular bases of efficacy and toxicity of chemotherapeutic agents often used for treatment of GI cancer such as CRC. Dr. Wafik S. El-Deiry from Brown University, as well as The Lifespan Health System, said, "Colorectal cancer (CRC) is the second leading cause of cancer death worldwide and its incidence has been steadily rising in recent decades, with nearly 2 million new cases diagnosed around the world in 2020."

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