Codiak BioSciences Reports Positive Initial Phase 1 Results for Its Exosome-Based IL-12 Vehicle (exoIL-12™) Demonstrating Tolerability and Absence of Systemic IL-12 Exposure in Healthy Volunteers

On Decembr 30, 2020, Codiak BioSciences, Inc. (NASDAQ: CDAK), a clinical-stage biopharmaceutical company focused on pioneering the development of exosome-based therapeutics as a new class of medicines, announced that the primary objectives were met in the initial part of its Phase 1 trial, which evaluated a single ascending dose of exoIL-12 in healthy volunteers. In this randomized, placebo controlled, double-blind study, exoIL-12 demonstrated a favorable safety and tolerability profile, with no local or systemic treatment-related adverse events and no detectable systemic exposure of IL-12. “This is an important milestone, as these results show that exoIL-12 acts in humans as we had expected, based on our preclinical evaluations. The safety and tolerability profile observed here support the target profile that we are hoping to achieve with this candidate,” said Benny Sorensen, MD, PhD, Senior Vice President and Head of Clinical Development, Codiak. “We’re looking forward to advancing exoIL-12 into the multi-dose part of the study in cutaneous T-cell lymphoma patients and presenting the detailed results from the healthy volunteer part of this study at an upcoming medical conference.”
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