Exosomes, as a potential biomarker in liquid biopsy, hold great potential for early cancer diagnosis and monitoring of highly metastatic cancer cells. Recently, a group of researchers proposed a novel electrochemical biosensor for sensitive identification and detection of target exosomes. The biosensor, based on 2D MXene membranes decorated with hierarchical Au nanoarrays, shows satisfactory reproducibility, wide linear range, and high sensitivity for exosome sensing. Exosomes (image at left) are small extracellular vesicles (EVs) with a size range of 30–150 nm that are released by tumor cells and other cells. Electrochemical biosensors, which are highly sensitive and selective with wide linear range and low cost, can be regarded as a suitable analytical platform for exosome measurement. In the current work, Wenfei Dong, PhD, and his team at the Suzhou Institute of Biomedical Engineering and Technology (SIBET) of the Chinese Academy of Sciences chose MXene nanosheets, a two-dimensional material with large surface area, high electrical conductivity, and catalytic ability, as the building blocks of MXene membrane preparation via facile vacuum filtration.
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