Cell-Derived Therapy (Exosomes) May Help Repair Abnormal Heart Rhythms & Reduce Scarring After Heart Attack; Research Is “Poised to Turn This Entire Field on Its Head,” Yale Experts State in Editorial; It Is “A Paradigm-Shifting Body of Work” by Cedars-Sinai Researchers

Vesicles (specifically, exosomes) (image) secreted from human heart cells may repair damaged tissue and prevent lethal heart rhythm disorders, according to a new study from investigators in the Smidt Heart Institute at Cedars-Sinai. The research, published on March 9, 2022 in the European Heart Journal, could lead to a new way to treat a heart rhythm problem called ventricular arrhythmia—a top cause of sudden cardiac death. In an accompanying editorial, experts describe the research as “poised to turn this entire field on its head.”  The article is titled “Biological Substrate Modification Suppresses Ventricular Arrhythmias in a Porcine Model of Chronic Ischaemic Cardiomyopathy.”