Recent dog breeding practices have loaded up cavalier King Charles spaniels with disease-causing mutations, including variants linked to the common heart condition, myxomatous mitral valve disease (MMVD). Erik Axelsson, PhD, of Uppsala University and colleagues published these new findings online on September 2, 2021 in PLOS Genetics. The open-access article is titled “The Genetic Consequences of Dog Breed Formation—Accumulation of Deleterious Genetic Variation and Fixation of Mutations Associated with Myxomatous Mitral Valve Disease in Cavalier King Charles Spaniels.”
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