Brain Metastases in Patients with Kidney Cancer May Have Immune-Suppressive Tumor Microenvironments; Single-Nucleus RNA Sequencing and Spatial Transcriptomics Used to Identify Potential Therapeutic Targets in Brain Metastases; Results Presented at AACR 2023

In patients with renal cell carcinoma, brain metastases had distinct gene expression
programs and lower antitumor immune cell infiltration than primary tumors or metastases in other organs, according to a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2023, held April 14-19 in Orlando, Florida. Recent studies have suggested that brain metastases might occur in over 25 percent of patients with
renal cell carcinoma who are treated with immune checkpoint inhibition, said Elshad Hasanov, MD, PhD, the presenter of the study and a medical oncology fellow at The University of Texas MD Anderson Cancer Center.