Blood-Stage Malaria Infection Suppresses Liver-Stage Development Through Interferon-Mediated Host Responses

by Medical Writer Alejandra Viviescas, PhD

Researchers at the Center for Global Infectious Disease Research, Seattle Children’s Research Institute, have discovered that malaria parasites in the bloodstream suppress the development of parasites from subsequent infections. The suppression is mediated by host interferons activated by the bloodstream infection. These findings have implications for the development of live-attenuated Plasmodium parasite vaccines, particularly in malaria-endemic areas where concomitant infections are common.

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