Biomarker Family Found for Chemo-Resistant Breast Cancers

Biomarkers that could help predict resistance to chemotherapy in breast cancer patients have been identified by researchers from the University of Hull, UK. The researchers found a family of proteins to be twice as prevalent in clinical samples obtained from breast cancer patients who were resistant to chemotherapy than in samples from patients who were successfully treated. Chemotherapy resistance is a major problem for some types of breast cancer and many patients undergo treatment that does not work, delaying other more suitable treatments and subjecting the patient to adverse side effects in the process. Published online on April 3, 2012 in the Journal of Proteomics, the Hull research identifies a number of potential biomarkers associated with resistance to common chemotherapy drugs, including epirubicin and docetaxel. Lead researcher Dr. Lynn Cawkwell says, "A major goal in cancer research is to be able to predict the response of a patient to chemotherapy. Unfortunately, a reliable test has not yet been developed to achieve this. We hope our work can help to bring us a step closer. Most of my work uses clinical samples instead of cell lines, thanks to the links I have with oncologists and surgeons at Castle Hill Hospital in Hull. Studying clinical samples gives a more accurate representation of what is relevant in real-life diseases." The project used two high-throughput processes to screen clinical samples of breast tumour tissue. One screening method using antibodies identified 38 proteins that were twice as prevalent in samples from patients who were resistant to chemotherapy than in samples from those who were successfully treated. The other screening method used mass spectrometry and uncovered 57 potential biomarkers, of which 5 belong to the 14-3-3 protein family.
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