Acoustic Microfluidic Device Can Gently and Rapidly Isolate Exosomes from Blood; Isolated Exosomes Can Be Analyzed for Molecular Signatures of Cancer and Other Diseases

Cells secrete nanoscale membraned packets called exosomes that can carry important messages from one part of the body to another. Scientists from MIT and other institutions have now devised a way to intercept these messages, which could be used to diagnose problems such as cancer or fetal abnormalities. Their new device uses a combination of microfluidics and sound waves to isolate these exosomes from blood. The researchers hope to incorporate this technology into a portable device that could analyze patient blood samples for rapid diagnosis, without involving the cumbersome and time-consuming ultracentrifugation method commonly used today. “These exosomes often contain specific molecules that are a signature of certain abnormalities. If you isolate them from blood, you can do biological analysis and see what they reveal,” says Dr. Ming Dao, a principal research scientist in MIT’s Department of Materials Science and Engineering and a senior author of the study, which appears in PNAS the week of September 18, 2017. The paper’s senior authors also include Dr. Subra Suresh, President-Designate of Nanyang Technological University in Singapore, MIT’s Vannevar Bush Professor of Engineering Emeritus, and a former Dean of Engineering at MIT; Dr. Tony Jun Huang, a Professor of Mechanical Engineering and Materials Science at Duke University; and Dr. Yoel Sadovsky, Director of the Magee-Women’s Research Institutein Pittsburgh.
Login Or Register To Read Full Story