On April 1, 2022, it was announced that the American Association for Cancer Research (AACR) will honor Ira Mellman, PhD, Fellow of the AACR Academy, with the 2022 AACR-Cancer Research Institute (CRI) Lloyd J. Old Award in Cancer Immunology at the AACR Annual Meeting 2022 in New Orleans, April 8-13, 2022. Dr. Mellman is the Vice President of Cancer Immunology at Genentech and an adjunct professor at the University of California, San Francisco (UCSF). He is being honored for his seminal contributions to characterizing dendritic cell function, and for applying these learnings to advance atezolizumab (Tecentriq) and neoepitope vaccines into the clinic. The AACR-CRI Lloyd J. Old Award in Cancer Immunology recognizes an active scientist whose outstanding and innovative research has made a major impact on the cancer field and has the potential to stimulate new directions in cancer immunology.