The American Association for Cancer Research (AACR) Project GENIE (Genomics Evidence Neoplasia Information Exchange) celebrated its six-year anniversary in November 2021. Project GENIE is a publicly accessible, international cancer registry of real-world data assembled through data-sharing among 19 of the leading cancer centers in the world. Several presentations at the AACR Annual Meeting 2022 featured projects that are using data from the registry to answer their important research questions. “This speaks to how more and more people are using and aware of the information that is available through the GENIE registry,” said Philippe L. Bedard, MD, UHN Toronto General Hospital, Toronto, Canada. The AACR Annual Meeting was held April 8-13 in New Orleans. Over 19,000 scientists and physicians registered for this premier cancer conference, with ~80% (~15,200) attending in person and ~20% (~3,800) attending virtually. The AACR has over 50,000 members worldwide. On Sunday, April 10, Dr. Bedard chaired a special session at the Annual Meeting that included presentations from several projects describing how they’re using data from Project GENIE to decode the complexities of cancer. That session, Decoding Cancer Complexity and Transforming Patient Outcomes Using AACR Project GENIE, and others can be viewed on the virtual platform by registered meeting participants through July 13, 2022. Registration can be done here.