It is my privilege to welcome you to the AACR Annual Meeting 2023--the 114th Annual Meeting of the American Association for Cancer Research (AACR). We hope you will enjoy reading all the great coverage and highlights of our meeting in AACR Annual Meeting News whether you are attending in person or joining virtually. We have assembled a robust multidisciplinary program for the meeting, united by the theme of “Advancing the Frontiers of Cancer Science and Medicine.” The theme reflects the AACR’s commitment to operating at the cutting edge of cancer research, setting a standard for the field that will transform patient outcomes. We are proud to showcase the latest advances in the etiology, biology, prevention, detection, diagnosis, and treatment of cancer, as well as the state-of-the-art concepts and technologies shaping cancer research today.